Olav 3R winner 2019

Norecopa's 3R Prize

The winner in 2019 was Arne Olav Melleby at Oslo University Hospital Ullevål, for his excellent work in developing a better operating technique for mice in research on chronic cardiac failure.

Read the paper in Cardiovascular Research describing the technique.

Norecopa is Norway's National Consensus Platform for the advancement of "the 3 Rs" (Replacement, Reduction, Refinement) in connection with animal experiments.Read more about Norecopa.

Photo: Member of Parliament Morten Ørsal Johanse handed over the Diploma for the Norecopa's 3R Prize for outstanding efforts to advance Replacement, Reduction & Refinement in connection with animal research, to the winner Arne Olav Melleby.

17th Annual CHFR Symposium on Heart Research

17th Annual CHFR Symposium on Heart Research

Wednesday September 18th to Friday September 20th, 2019

- Wednesday NORHEART Cardiac Café - the place to meet and be inspired!

- Thursday to Friday 17th Annual CHFR Symposium on Heart Research. Holmenkollen Park Hotel, Oslo, Norway. The symposium arranged by Center for heart failure research and NORHEART is open to all clinical and basic researchers, and provides a unique meeting place for regional, national and international interaction.

Submission of abstracts before Monday 3rd of June
Registration before Monday 20th of August.
Submission of presentation before Wednesday 11th of September.

All seminar attendees must register. There is no registration fee.

Click here for more information and registration.

Journal of Biological Chemistry

Latest publication (May 2019)

Sabrina Bech Mathiesen, Marianne Lunde, Jan Magnus Aronsen, Andreas Romaine, Anita Kaupang, Marita Martinsen, Gustavo, Antonio de Souza, Tuula A. Nyman, Ivar Sjaastad, Geir Christensen, and Cathrine Rein Carlson

The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)

Read the article in The Journal of Biological Chemistry

PMID: 30967474. DOI: 10.1074/jbc.RA118.006423

Zoltan Barth 2016

Doctoral Thesis: May 10, 2019

MD Zoltan Barth will defend his thesis for the degree of Ph.D. (philosophiae doctor): “Microvascular Remodelling and Autonomic Dysregulation in Juvenile Dermatomyositis”

Given topic: "Nailfold capillaroscopy findings as predictor of organ involvement in juvenile and adult systemic sclerosis (scleroderma)."

Trial lecture: May 10, 2019 10:15 AM

Dissertation: May 10, 2019 1:15 PM

Venue: Seminarrom A3 3067, Rikshospitalet, Sognsvannsveien 20

Supervisor: MD, PhD Helga Sanner, Oslo University Hospital

Read more...

Am.J Physiol Lung Cell Mol.Physiol

Latest publication (April 2019)

Camilla Udjus, Fadila T. Cero, Bente Halvorsen, Dina Behmen, Cathrine R. Carlson, Bård A. Bendiksen, Emil K. Espe, Ivar Sjaastad, Else Marit Løberg, Arne Yndestad, Pål Aukrust, Geir Christensen, Ole Henning Skjønsberg and Karl Otto Larsen

Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension

Read the article in American Journal of Physiology. Lung Cellular and Molecular Physiology

PMID: 30908936 DOI: 10.1152/ajplung.00322.2018

The Journal of Rheumatology

Latest publication (March 2019)

Birgit Nomeland Witczak, Siri Opsahl Hetlevik, Helga Sanner, Zoltan Barth, Thomas Schwartz, Berit Flatø, Vibke Lilleby and Ivar Sjaastad

Effect on Cardiac Function of Longstanding Juvenile-onset Mixed Connective Tissue Disease: A Controlled Study

Read the article in The Journal of Rheumatology
DOI: 10.3899/jrheum.180526

Journal of Physiology

Latest publication (February 2019)

David D. B. Lipsett, Michael Frisk, Jan Magnus Aronsen, Einar S. Nordén, Buonarati,O.R., Alessandro Cataliotti, Hell,J.W., Ivar Sjaastad, Geir Christensen and William E. Louch

Cardiomyocyte substructure reverts to an immature phenotype during heart failure

Read the article in The Journal of Physiology

PMID:30707448. doi: 10.1113/JP277273

American Journal of Physiology-cover

Latest publication (January 2019)

Jonas Skogestad, Glenn Terje Lines, William E. Louch, Ole M. Sejersted, Ivar Sjaastad, and Jan Magnus Aronsen

Evidence for heterogeneous subsarcolemmal Na+ levels in rat ventricular myocytes

Read the article in:
American Journal of Physiology-Heart and Circulatory Physiology

PMID: 30657726 DOI: 10.1152/ajpheart.00637.2018

Nasjonalforeningen300

Funding from the Norwegian Health Association

Nasjonalforeningen for folkehelsen (the Norwegian Health Association) combats cardiovascular disease and dementia by funding research.

This year PhD student Chloe Rixon and Postdocs Ornella Manfra, Jia Li, Emil Espe, Mari Elen Strand and Maria Vistnes have all been granted funding from the Norwegian Health Association. In addition running cost contributions are given for research projects lead by Principal investigators Ida Gjervold Lunde, Mathis Korseberg Stokke and Geir Christensen.

See all the projects supported by Nasjonalforeningen for folkehelsens hjerte- og karmidler 2019.

Next application submission deadline is 1st June 2019.
Calls for project proposals:
Søk forskningsmidler fra Nasjonalforeningen for folkehelsen.


Ornella, Chloe and Jia at Nasjonalforeningen research prize ceremony.

Cover Journal of Physiology, Volume 597 Number 2, 15 January 2019

Latest publication (December 2018)

Xin Shen, Jonas van den Brink, Yufeng Hou, Dylan Colli , Christopher Le, Terje R. Kolstad ,Niall MacQuaide, Cathrine R. Carlson, Peter M. Kekenes-Huskey, Andrew G. Edwards, Christian Soeller and William E. Louch.

3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes.

"In this issue of The Journal of Physiology, Shen and colleagues have employed the super-resolution imaging technique dSTORM to quantitatively describe the 3D, nanoscale arrangement of ryanodine receptors across rat ventricular cardiomyocytes. Combining dSTORM-derived ryanodine receptor positions with confocal images of t-tubules allows appreciation of the 3D complexity and irregularity of dyadic arrangements."
The Journal of Physiology, Volume 597 Number 2, 15 January 2019

Read the article in The Journal of Physiology

J Physiol. 2019 Jan;597(2):399-418. doi: 10.1113/JP277360.
PMID: 30412283 PMCID: PMC6332759

Microscopy_IEMR.2019

Super-resolution and Confocal Microscopy

Our institute is one of the nodes in a core facility for super-resolution and confocal microscopy supported by Helse Sør-Øst. This core facility includes two additional nodes located at Radiumhospitalet (Montebello) and Rikshospitalet (Gaustad).

A core facility is a laboratory with particularly advanced equipment that serves researchers both within and outside the unit.

Read more about:
Core Facility Super-resolution and Confocal Microscopy, Ullevål

LOGO_Jebsen_cardiac

K. G. Jebsen Centre for Cardiac Research at University of Oslo

K.G. Jebsen Centre for Cardiac Research is directed by Professor Ivar Sjaastad: "Our primary objective is to better understand the mechanisms of heart failure. Specifically, we will identify mechanisms regulating myocardial stiffness, and new therapeutic targets of diastolic dysfunction."

The centre comprises six research groups at University of Oslo; of which three are located at Ullevål Hospital, two at Rikshospitalet and one at Radiumhospitalet.

Group leaders: Ivar Sjaastad (Centre leader), Geir Christensen, (Deputy leader), William E. Louch, Camilla Raiborg, Thor Edvardsen and Lars Gullestad
Associated partners: Alessandro Cataliotti, Llewelyn Roderick (University of Cambridge), Joakim Sundnes (Simula) and Kjetil Taskén
Administrative coordinator: Emil Espe

Read more about the K.G. Jebsen Centre for Cardiac Research

Institute for Experimental Medical Research (IEMR)

Institutt for eksperimentell medisinsk forskning (IEMF)
Acting Institute leader: Professor Ivar Sjaastad

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www.iemf.no www.iemr.no

QuoteMicroscope
VISION and AIMS

Institute for Experimental
Medical Research (IEMR)

use cutting edge technologies to better understand the mechanisms of heart failure.


Our method competency is comprehensive, and streches from clinical studies to investigation of individual biomolecules.


OUR VISION
Excellent science reveals the secrets of the failing heart


OUR AIMS
Find novel targets for the treatment of heart failure patients.
Develop and employ cutting edge technologies to understand the mechanisms of heart failure.
Recruit and educate PhD and medical students to become tomorrow’s scientific experts.




Webmaster Vidar, IEMF