In vivo cardiac function

Echo with VisualSonics Vevo 2100
Echo with VisualSonics Vevo 2100

At the institute, we have equipment for advanced in vivo cardiac
phenotyping.

Echocardiography
A high resolution VisualSonics Vevo 2100 is available. With a 25 and 35 MHz
scanhead, the scanner can be used for smaller species. The equipment allows
detailed mapping of both cardiac structure and function, but is also
available for eg. cancer research.

We also have a Vivid 7 echocardiograph equipped with a M3S, M12L, i13L and
T6 scanheads. Thus, both standard echocardiography and transesophageal
examinations can be performed; the latter in larger species.

Telemetry
DSI telemetry with 16 transmitters allows high throughput monitoring of
cardiac rhythm, motion, temperature and blood pressure.

Pressure and PV-catheters
We have pressure catheters from Millar and Samba, and PV-catheters from
Millar. Pressure catheters allows invasive hemodynamic measurements and
accurate detection of cardiac function. Pressure-volume analysis allows pre-
and afterload-independent hemodynamic studies and measurement of cardiac
contractility in vivo, among others suitable for studying cardiac signaling
pathways and drug testing.

Exercise training
Treadmills from Columbus/Linton is available for exercise training of
smaller species.

Skeletal muscle function
In vivo skeletal muscle function can be tested with both isometric and
dynamic protocols. Setups from Aurora Instruments allows superior dynamic
control of force and length, and can be used for eg. acute exercise and
fatigue protocols.

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