Kristin H. Hortemo 5x7 300dpi

Doctoral Thesis: 19th of December 2016 Kristin Halvorsen Hortemo will defend her thesis for the degree of Ph.D. (philosophiae doctor): Fatigue mechanisms of shortening skeletal muscle: Protein phosphorylation and O-GlcNAcylation with emphasis on regulatory myosin light chain (MLC2).

Trial lecture: Muscle fatigue - challenges of protocol selection and outcome measures for the assessment of muscle function

Trial lecture: 19.12 2016 10:15

Dissertation: 19.12 2016 13:15

Venue: Auditoriet i Kreftsenteret, Oslo universitetssykehus, Ullevål, Kirkeveien 166

Supervisor: Professor Ole M. Sejersted, Institute for Experimental Medical Research, University of Oslo


Plos One

Latest publication November 2016

The heparan sulfate proteoglycan glypican-6 is upregulated in the failing heart, and regulates cardiomyocyte growth through ERK1/2 signaling

Arne O. Melleby, Mari E. Strand, Andreas Romaine, Kate M. Herum, Biljana Skrbic, Christen P. Dahl, Ivar Sjaastad, Arnt E. Fiane, Jorge Filmus, Geir Christensen & Ida G. Lunde

PLoS One, 11:10;e0165079

Logo utdrag fra Program 2016

Prize winners of the Poster Session, CHFR 2016

Presentations from our Institute which got first prize during the 14th Annual CHFR Symposium:

Ida Gjervold Lunde: II-8 Titin A-band truncation mutation in mice causes stress-induced dilated cardiomyopathy

Åsmund Treu Røe: IV-13 Elevated ventricular wall stress disrupts diastolic calcium homeostasis of the cardiomyocyte

Mari Elen Strand: VI-7 The heparanase-syndecan-4 axis in the heart: upregulation in response to immune activation indicates a role in cardiac inflammation

Other posters from our Institute which were ranked top 3 in their sessions, were presented by:

Jonas Skogestad, Xin Shen and Henriette Marstein


See all the Prize winners at Center for Heart Failure Research

Magnetic Resonance Imaging

Latest publication October 2016

A semiautomatic method for rapid segmentation of velocity encoded myocardial magnetic resonance imaging data

Emil K. Espe, Kristine Kristine Skårdal, Jan Magnus Aronsen, Lili Zhang, & Ivar Sjaastad

Magnetic Resonance Imaging. DOI 10.1002/mrm.26486

Physiological Reports

Latest publication September 2016

Exercise training increases protein O-GlcNAcylation in rat skeletal muscle

Kristin H. Hortemo, Per Kristian Lunde, Jan Haug Aronsen, Heidi Kvaløy, Morten Munkvik, Tommy A. Rehn, Ivar Sjaastad, Ida G. Lunde, Jan Magnus Aronsen, & Ole M. Sejersted

Physiol Rep, 4 (18), 2016, e12896. doi: 10.14814/phy2.12896

Nils Tovsrud  5x7

Doctoral Thesis: 9th of September 2016 Nils Tovsrud will defend his thesis for the degree of Ph.D. (philosophiae doctor): Na+ regulation of the cardiac excitation-contraction-relaxation coupling

Trial lecture: Altered calcium cycling and energy crisis in heart failure: novel approaches for disease treatment.

Trial lecture: 09.09 2016 10:15

Dissertation: 09.09 2016 13:15

Venue: Auditoriet, Kreftsenteret, Bygning 11, Oslo Universitetssykehus Ullevål, Kirkeveien 166

Supervisor: Senior Adviser Fredrik Swift, Norwegian Institute of Public Health, Oslo


Biljana Skrbic 5x7

Doctoral Thesis: 9th of September 2016

MD Biljana Skrbic will defend her thesis for the degree of Ph.D. (philosophiae doctor): New aspects in myocardial remodeling and dysfunction due to left ventricular pressure overload

Trial lecture: Hvorfor er veien så lang fra dyre-eksperimenter til klinisk medisin?

Trial lecture: 09.09 2016 11:15

Dissertation: 09.09 2016 13:15

Venue: Rødt Auditorium, Laboratoriebygget 25, Oslo Universitetssykehus Ullevål, Kirkeveien 166

Supervisor: Professor Theis Tønnessen, Institute of Clinical Medicine, University of Oslo


Biochemical Journal

Latest publication August 2016

Development of high affinity peptides that prevent phospholemman (PLM) inhibition of the sodium-calcium exchanger 1 (NCX1)

Pimthanya Wanichawan, Kjetil Hodne, Tandekile L. Hafver, Marianne Lunde, Marita Martinsen, William E. Louch, Ole M. Sejersted, & Cathrine R. Carlson

Biochem J, 473:2413-2423

Read the article in Biochemical Journal

Cell Tissue Research

Latest publication July 2016

Syndecans in heart fibrosis

Ida G. Lunde, Kate M. Herum, Cathrine C. Carlson & Geir Christensen

Cell Tissue Res 2016 July 14. doi: 10.1007/s00441-016-2454-2

Read this Review-article in Cell and Tissue Research

Cardiovascular Research

Latest publication June 2016

Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release

Ravinea Manotheepan, Tore Kristian Danielsen, Mani Sadredini, Mark E. Anderson, Cathrine R. Carlson, Stephan E. Lehnart, Ivar Sjaastad, Mathis K. Stokke,

Cardiovasc Res 2016 May 8. doi: 10.1093/cvr/cvw095

Read the article in Cardiovascular Research

Cardiovascular Research

Latest publication May 2016

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis.

Michael Frisk, Marianne Ruud, Emil K Stenersen Espe, J Magnus Aronsen, Åsmund T Røe, Lili Zhang, Per Andreas Norseng, Ole M Sejersted, Geir Christensen, Ivar Sjaastad, William E Louch

Cardiovasc Res 2016 May 25. Epub 2016 May 25.


Read the article in Cardiovascular Research

plos one science

Latest publication April 2016

Beta-adrenoceptor stimulation reveals Ca2+ waves and sarcoplasmic reticulum Ca2+ depletion in left ventricular cardiomyocytes from post-infarction rats with and without heart failure

Mani N. Sadredini, Tore Kristian Danielsen, Jon Magnus Aronsen, Ravinea Manotheepan, Karina Hougen, Ivar Sjaastad and Mathis K. Stokke

PLoS ONE 11(4): e0153887. doi:10.1371/journal.pone.0153887

Read the article in Open Access journal, PLOS ONE

Annual Report 2015 cover

Annual Report IEMR 2015

Several new postdocs and PhD students were hired in 2015. Altogether we had the pleasure of welcoming 11 new people to IEMR. The core staff now counts 72 people at the institute and about 15 people that are employed other places do their entire project or parts of it at IEMR.

Six theses were defended in 2015, and altogether 35 articles were published, many of them in collaboration with colleagues abroad. One paper was selected as one of the six best publications from the hospital in the spring 2015. The institute is host to three regional core facilities.

Read the Annual Report IEMR 2015

plos one science

Latest publication March 2016

Kristine Skårdal, Emil KS Espe, Lili Zhang, Jan Magnus Aronsen and Ivar Sjaastad

Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance

Published: March 1, 2016
DOI: 10.1371/journal.pone.0150536

Read the article in Open Access journal, PLOS ONE

Mari Elen Strand 5x7

Doctoral Thesis: 18th of February 2016 Mari Elen Strand will defend her thesis for the degree of Ph.D. (philosophiae doctor): The extracellular matrix in heart failure: Proteoglycans and collagens as regulators of inflammation, fibrosis and cardiac dysfunction.

Trial lecture:
Current Understanding of the Pathophysiology of Heart Failure.

Trial lecture: 18. feb. 2016 10:15

Dissertation: 18. feb. 2016 13:15

Venue: Rødt auditorium, Laboratoriebygget (bygg 25), Ullevål sykehus, Kirkeveien 166, Oslo

Supervisor: postdoc. Ida Gjervold Lunde, Institute of Clinical Medicine, University of Oslo


Scandinavian Cardiovascular Journal

Latest publication February 2016

Jan Magnus Aronsen, William E. Louch, Ivar Sjaastad

Cardiomyocyte Ca2+ dynamics: clinical perspectives

DOI: 10.3109/14017431.2015.1136079

Read the article in Scandinavian Cardiovascular Journal

JBC -Journal of Biological Chemistry cover

Latest publication January 2016

Tandekile Lubelwana Hafver, Kjetil Hodne, Pimthanya Wanichawan, Jan Magnus Aronsen, Bjørn Dalhus, Per Kristian Lunde, Marianne Lunde, Marita Martinsen, Ulla Helene Enger, William Fuller, Ivar Sjaastad, William Edward Louch, Ole Mathias Sejersted and Cathrine Rein Carlson

Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger1 Regulates its Activity by Dephosphorylating Serine 68 Phosphorylated Phospholemman

doi: 10.1074/jbc.M115.677898

Read the article in JBC -Journal of Biological Chemistry.

Rheumatology December 2015  54 (12)

Latest publication

Zoltan Barth, Birgit Nomeland Witczak, Thomas Schwartz, Knut Gjesdal, Berit Flatø, Akos Koller, Helga Sanner and Ivar Sjaastad.

In juvenile dermatomyositis, heart rate variability is reduced, and associated with both cardiac dysfunction and markers of inflammation: a cross-sectional study median 13.5 years
after symptom onset

doi: 10.1093/rheumatology/kev376

Read the article in Rheumatology .


Institute for Experimental Medical Research (IEMR)

Institutt for eksperimentell medisinsk forskning (IEMF)
Head of Institute: Professor Ole M. Sejersted, MD, Ph.D.

Click for Address Information

Please read the documents:
- Research Groups & Available Methods
- IEMR Annual report 2015 (PDF)

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